On November 13, 2017, the international academic journal "Nature Medicine" published the research results of "Enhancing the genetic lineage tracing using dual recombinases" by Zhou Bin Research Group of the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.As a new lineage tracing technique, DeaLT contains two strategies, DeaLT-IR and DeaLT-NR; it can effectively circumvent the non-specificity of Cre expression in the traditional Cre-loxP homologous recombination system. Heterogeneous homologous recombination enables more precise genetic lineage tracin...
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2018
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In Dec. 2016, the Nature journal published a new strategy for gene editing (homology independent targeted integration, HITI), which developed by the team of Juan Izpisua Belmonte in the Salk Institute. Their study proved that HITI can be used for gene editing in vitro and in vivo efficiently, and may be very important for basic research and targeted gene therapy in future! Suzuki, K. et al. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature 540, 144-149 (2016).
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2018
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